The venous tone is not altered after three-week tail suspension in rats.

Détails

ID Serval
serval:BIB_2D59AB480D99
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The venous tone is not altered after three-week tail suspension in rats.
Périodique
Journal of Gravitational Physiology
Auteur(s)
Louisy F., Tran C.C., Resch G., Luce P., Lemarquer F., Finet M.
ISSN
1077-9248 (Print)
ISSN-L
1077-9248
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
5
Numéro
1
Pages
P47-8
Langue
anglais
Résumé
Cardiovascular deconditioning observed in humans during spaceflight has been suggested to be related in part to changes in venous compliance, mechanisms including skeletal muscle deconditioning. However, increased venous compliance was observed during very short term simulations (24 to 48 hours), and during an over 28-day simulation the hyperdistensibility tended to decrease whereas the muscular changes were still present (2). In the first case, muscular changes can not explain the venous alterations because of the short delay. In the second case, the relationship between muscular and venous alterations disappeared. Finally, it is suggested that factors other than muscular ones could explain the changes in venous compliance observed during spaceflights. The fact that orthostatic hypotension has never been observed after hindlimb suspension in the rat raises issue with the use of tail-suspended rats as a valid model for the study of the mechanisms involved in cardiovascular deconditioning induced by spaceflight in humans. However, in vitro altered responsiveness of the vena cava to norepinephrine were observed in rat after spaceflight and tail suspension. The purpose of the experiments was to verify if any change occurs in venous tone measured in vivo in rats after three-week tail suspension.

Mots-clé
Animals, Blood Pressure/physiology, Central Venous Pressure/physiology, Compliance, Hindlimb Suspension, Male, Rats, Veins/anatomy & histology, Veins/physiology, Venous Pressure/physiology, Weightlessness Simulation/methods
Pubmed
Création de la notice
17/02/2017 9:01
Dernière modification de la notice
20/08/2019 13:12
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