Selective Testing of At-Risk Blood Donors for Trypanosoma cruzi and Plasmodium spp. in Switzerland.

Détails

ID Serval
serval:BIB_2D35E74B2D67
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Selective Testing of At-Risk Blood Donors for Trypanosoma cruzi and Plasmodium spp. in Switzerland.
Périodique
Transfusion medicine and hemotherapy
Auteur⸱e⸱s
Niederhauser C., Gottschalk J., Tinguely C.
ISSN
1660-3796 (Print)
ISSN-L
1660-3796
Statut éditorial
Publié
Date de publication
05/2016
Peer-reviewed
Oui
Volume
43
Numéro
3
Pages
169-176
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Population migrations and overseas recreational travel to regions at risk for tropical diseases are increasing. A major challenge in non-endemic countries is to decrease the number of blood donor deferrals due those tropical disease pathogens, without compromising the high level of blood safety. The protozoans Trypanosoma cruzi and Plasmodium spp., the causative organisms of Chagas disease (CD) and malaria are becoming a major focus in the blood transfusion community.
National guidelines of the Blood Transfusion Service of the Swiss Red Cross propose an algorithm for dealing with these pathogens, including a mandatory selective serological testing of donors at risk.
6,978 donors at risk for CD were tested. Three of them were confirmed anti-T. cruzi -positive, and in one case a transfusion-transmitted infection was highly possible. The specificity of the assay was 99.94%. For malaria 12,887 donors were at risk and 178 were confirmed positive. The specificity of the assays was 92.8%.
CD and malaria in non-endemic countries may represent a certain risk for blood transfusion. Switzerland chose a selective testing approach. The specificity of the assays is a crucial topic for this approach because it ensures a minimal loss of false-reactive donors and helps towards an easier counselling of implicated donors.

Mots-clé
Chagas, Malaria, Plasmodium spp, Selective testing, Trypanosoma cruzi
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/01/2018 11:28
Dernière modification de la notice
21/08/2019 5:33
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