Small RNAs as regulators of primary and secondary metabolism in Pseudomonas species.

Détails

ID Serval
serval:BIB_2D323B6AD373
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Small RNAs as regulators of primary and secondary metabolism in Pseudomonas species.
Périodique
Applied Microbiology and Biotechnology
Auteur⸱e⸱s
Sonnleitner E., Haas D.
ISSN
1432-0614 (Electronic)
ISSN-L
0175-7598
Statut éditorial
Publié
Date de publication
2011
Volume
91
Numéro
1
Pages
63-79
Langue
anglais
Résumé
Small RNAs (sRNAs) exert important functions in pseudomonads. Classical sRNAs comprise the 4.5S, 6S, 10Sa and 10Sb RNAs, which are known in enteric bacteria as part of the signal recognition particle, a regulatory component of RNA polymerase, transfer-messenger RNA (tmRNA) and the RNA component of RNase P, respectively. Their homologues in pseudomonads are presumed to have analogous functions. Other sRNAs of pseudomonads generally have little or no sequence similarity with sRNAs of enteric bacteria. Numerous sRNAs repress or activate the translation of target mRNAs by a base-pairing mechanism. Examples of this group in Pseudomonas aeruginosa are the iron-repressible PrrF1 and PrrF2 sRNAs, which repress the translation of genes encoding iron-containing proteins, and PhrS, an anaerobically inducible sRNA, which activates the expression of PqsR, a regulator of the Pseudomonas quinolone signal. Other sRNAs sequester RNA-binding proteins that act as translational repressors. Examples of this group in P. aeruginosa include RsmY and RsmZ, which are central regulatory elements in the GacS/GacA signal transduction pathway, and CrcZ, which is a key regulator in the CbrA/CbrB signal transduction pathway. These pathways largely control the extracellular activities (including virulence traits) and the selection of the energetically most favourable carbon sources, respectively, in pseudomonads.
Mots-clé
Gene Expression Regulation, Bacterial, Genes, Regulator, Pseudomonas/genetics, Pseudomonas/metabolism, RNA, Bacterial/genetics, RNA, Bacterial/metabolism, RNA, Untranslated/genetics, RNA, Untranslated/metabolism
Pubmed
Web of science
Création de la notice
16/02/2012 9:48
Dernière modification de la notice
20/08/2019 13:12
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