Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_2C8FE69EB561
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
Périodique
Cancer cell
Auteur⸱e⸱s
Pajtler K.W., Witt H., Sill M., Jones D.T., Hovestadt V., Kratochwil F., Wani K., Tatevossian R., Punchihewa C., Johann P., Reimand J., Warnatz H.J., Ryzhova M., Mack S., Ramaswamy V., Capper D., Schweizer L., Sieber L., Wittmann A., Huang Z., van Sluis P., Volckmann R., Koster J., Versteeg R., Fults D., Toledano H., Avigad S., Hoffman L.M., Donson A.M., Foreman N., Hewer E., Zitterbart K., Gilbert M., Armstrong T.S., Gupta N., Allen J.C., Karajannis M.A., Zagzag D., Hasselblatt M., Kulozik A.E., Witt O., Collins V.P., von Hoff K., Rutkowski S., Pietsch T., Bader G., Yaspo M.L., von Deimling A., Lichter P., Taylor M.D., Gilbertson R., Ellison D.W., Aldape K., Korshunov A., Kool M., Pfister S.M.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Statut éditorial
Publié
Date de publication
11/05/2015
Peer-reviewed
Oui
Volume
27
Numéro
5
Pages
728-743
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Mots-clé
Adaptor Proteins, Signal Transducing/genetics, Adolescent, Adult, Age Factors, Aged, Central Nervous System Neoplasms/classification, Central Nervous System Neoplasms/genetics, Central Nervous System Neoplasms/pathology, Child, Child, Preschool, DNA Methylation, Ependymoma/classification, Ependymoma/genetics, Ependymoma/pathology, Female, Gene Dosage, Gene Expression Profiling, Gene Fusion, Humans, Infant, Male, Middle Aged, Phosphoproteins/genetics, Transcription Factors, Transcription, Genetic, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/08/2020 13:02
Dernière modification de la notice
10/11/2020 7:26
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