Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis.

Détails

ID Serval
serval:BIB_2C8082AD17F4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis.
Périodique
Journal of Immunology
Auteur⸱e⸱s
Antsiferova M., Martin C., Huber M., Feyerabend T.B., Förster A., Hartmann K., Rodewald H.R., Hohl D., Werner S.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2013
Volume
191
Numéro
12
Pages
6147-6155
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The growth and differentiation factor activin A is a key regulator of tissue repair, inflammation, fibrosis, and tumorigenesis. However, the cellular targets, which mediate the different activin functions, are still largely unknown. In this study, we show that activin increases the number of mature mast cells in mouse skin in vivo. To determine the relevance of this finding for wound healing and skin carcinogenesis, we mated activin transgenic mice with CreMaster mice, which are characterized by Cre recombinase-mediated mast cell eradication. Using single- and double-mutant mice, we show that loss of mast cells neither affected the stimulatory effect of overexpressed activin on granulation tissue formation and reepithelialization of skin wounds nor its protumorigenic activity in a model of chemically induced skin carcinogenesis. Furthermore, mast cell deficiency did not alter wounding-induced inflammation and new tissue formation or chemically induced angiogenesis and tumorigenesis in mice with normal activin levels. These findings reveal that mast cells are not major targets of activin during wound healing and skin cancer development and also argue against nonredundant functions of mast cells in wound healing and skin carcinogenesis in general.
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/01/2014 16:35
Dernière modification de la notice
20/08/2019 13:11
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