Synchronous tumors of the pancreas and the gallbladder: a case report with targeted NGS evaluation.

Détails

Ressource 1Télécharger: atm-07-22-696.pdf (1445.43 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_2C6527444F7B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Synchronous tumors of the pancreas and the gallbladder: a case report with targeted NGS evaluation.
Périodique
Annals of translational medicine
Auteur(s)
Sivade A., Sempoux C., Voutsadakis I., Brunel C., Halkic N., Godat S., Duran R., Digklia A.
ISSN
2305-5839 (Print)
ISSN-L
2305-5839
Statut éditorial
Publié
Date de publication
11/2019
Peer-reviewed
Oui
Volume
7
Numéro
22
Pages
696
Langue
anglais
Notes
Publication types: Case Reports
Publication Status: ppublish
Résumé
Synchronous tumors of the pancreas and gallbladder are rare and often attributed to an abnormal pancreato-biliary junction, which results in a persistent reflux of pancreatic secretions leading to chronic biliary inflammation. We present the case of a 73-year-old woman with synchronous lesions of the pancreas and gallbladder initially considered as two primary localized cancers and treated with curative intent. At relapse, targeted next generation sequencing (NGS), performed in search of potential therapeutic targets, uncovered the fact that the two lesions appeared to be clonally related. This case illustrates the problem of synchronous lesions of the pancreas and gallbladder. New pathologic assessments with comparative molecular analysis of mutational profiles may be helpful in this context.
Mots-clé
HER2, Next generation sequencing (NGS), cancer, gallbladder
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/10/2020 11:29
Dernière modification de la notice
25/02/2021 7:08
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