Hedgehog Signaling in Malignant Pleural Mesothelioma.

Détails

ID Serval
serval:BIB_2C17D353BF62
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Hedgehog Signaling in Malignant Pleural Mesothelioma.
Périodique
Genes
Auteur(s)
Felley-Bosco E., Opitz I., Meerang M.
ISSN
2073-4425 (Electronic)
ISSN-L
2073-4425
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
6
Numéro
3
Pages
500-511
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: epublish
Résumé
Malignant pleural mesothelioma (MPM) is a cancer associated with exposure to asbestos fibers, which accumulate in the pleural space, damage tissue and stimulate regeneration. Hedgehog signaling is a pathway important during embryonic mesothelium development and is inactivated in adult mesothelium. The pathway is reactivated in some MPM patients with poor clinical outcome, mainly mediated by the expression of the ligands. Nevertheless, mutations in components of the pathway have been observed in a few cases. Data from different MPM animal models and primary culture suggest that both autocrine and paracrine Hedgehog signaling are important to maintain tumor growth. Drugs inhibiting the pathway at the level of the smoothened receptor (Smo) or glioma-associated protein transcription factors (Gli) have been used mostly in experimental models. For clinical development, biomarkers are necessary for the selection of patients who can benefit from Hedgehog signaling inhibition.
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/08/2015 7:42
Dernière modification de la notice
20/08/2019 13:11
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