Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia.

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Accès restreint UNIL
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_2C0C551FFDA0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia.
Périodique
Neuroscience
Auteur⸱e⸱s
Paolicelli R.C., Bergamini G., Rajendran L.
ISSN
1873-7544 (Electronic)
ISSN-L
0306-4522
Statut éditorial
Publié
Date de publication
01/05/2019
Peer-reviewed
Oui
Volume
405
Pages
148-157
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Extracellular vesicles, including exosomes and microvesicles, are small, nano-to-micrometer vesicles that are released from cells. While initially observed in immune cells and reticulocytes as vesicles meant to remove archaic proteins, now they have been observed in almost all cell types of multicellular organisms. Growing evidence indicates that extracellular vesicles, containing lipids, proteins and RNAs, represent an efficient way to transfer functional cargoes from one cell to another. In the central nervous system, the extensive cross-talk ongoing between neurons and glia, including microglia, the immune cells of the brain, takes advantage of secreted vesicles, which mediate intercellular communication over long range distance. Recent literature supports a critical role for extracellular vesicles in mediating complex and coordinated communication among neurons, astrocytes and microglia, both in the healthy and in the diseased brain. In this review, we focus on the biogenesis and function of microglia-related extracellular vesicles and focus on their putative role in Alzheimer's disease pathology.
Mots-clé
Alzheimer’s disease, exosomes, extracellular vesicles, microglia, microvesicles, neurons
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/12/2018 10:55
Dernière modification de la notice
19/07/2022 14:00
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