Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation.

Détails

ID Serval
serval:BIB_2B503C2B3AD5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation.
Périodique
Current opinion in genetics & development
Auteur(s)
Sancho-Martinez I., Ocampo A., Izpisua Belmonte J.C.
ISSN
1879-0380 (Electronic)
ISSN-L
0959-437X
Statut éditorial
Publié
Date de publication
10/2014
Peer-reviewed
Oui
Volume
28
Pages
57-63
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Review
Publication Status: ppublish
Résumé
The generation of human induced pluripotent stem cells (iPS) has raised enormous expectations within the biomedical community due to their potential vast implications in regenerative and personalized medicine. However, reprogramming to iPS is still not fully comprehended. Difficulties found in ascribing specific molecular patterns to pluripotent cells (PSCs), and inherent inter-line and intra-line variability between different PSCs need to be resolved. Additionally, and despite multiple assumptions, it remains unclear whether the current in vitro culturing conditions for the maintenance and differentiation of PSCs do indeed recapitulate the developmental processes observed in vivo. As a consequence, basic questions such as what is the actual nature of PSCs remain unanswered and different theories have emerged in regards to the identity of these valuable cell population. Here we discuss on the published theories for defining PSC identity, the implications that the different postulated models have for the reprogramming field as well as speculate on potential future directions that might be opened once a precise knowledge on the nature of PSCs is accomplished.
Mots-clé
Animals, Cell Differentiation, Cell Lineage, Cellular Reprogramming, Humans, Pluripotent Stem Cells/cytology
Pubmed
Web of science
Création de la notice
14/08/2018 9:37
Dernière modification de la notice
20/08/2019 13:10
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