A Monte Carlo model for the internal dosimetry of choroid plexuses in nuclear medicine procedures.

Détails

ID Serval
serval:BIB_2B4DBA3A6354
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A Monte Carlo model for the internal dosimetry of choroid plexuses in nuclear medicine procedures.
Périodique
Physica medica
Auteur⸱e⸱s
Amato E., Cicone F., Auditore L., Baldari S., Prior J.O., Gnesin S.
ISSN
1724-191X (Electronic)
ISSN-L
1120-1797
Statut éditorial
Publié
Date de publication
05/2018
Peer-reviewed
Oui
Volume
49
Pages
52-57
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Choroid plexuses are vascular structures located in the brain ventricles, showing specific uptake of some diagnostic and therapeutic radiopharmaceuticals currently under clinical investigation, such as integrin-binding arginine-glycine-aspartic acid (RGD) peptides. No specific geometry for choroid plexuses has been implemented in commercially available software for internal dosimetry. The aims of the present study were to assess the dependence of absorbed dose to the choroid plexuses on the organ geometry implemented in Monte Carlo simulations, and to propose an analytical model for the internal dosimetry of these structures for <sup>18</sup> F, <sup>64</sup> Cu, <sup>67</sup> Cu, <sup>68</sup> Ga, <sup>90</sup> Y, <sup>131</sup> I and <sup>177</sup> Lu nuclides. A GAMOS Monte Carlo simulation based on direct organ segmentation was taken as the gold standard to validate a second simulation based on a simplified geometrical model of the choroid plexuses. Both simulations were compared with the OLINDA/EXM sphere model. The gold standard and the simplified geometrical model gave similar dosimetry results (dose difference < 3.5%), indicating that the latter can be considered as a satisfactory approximation of the real geometry. In contrast, the sphere model systematically overestimated the absorbed dose compared to both Monte Carlo models (range: 4-50% dose difference), depending on the isotope energy and organ mass. Therefore, the simplified geometric model was adopted to introduce an analytical approach for choroid plexuses dosimetry in the mass range 2-16 g. The proposed model enables the estimation of the choroid plexuses dose by a simple bi-parametric function, once the organ mass and the residence time of the radiopharmaceutical under investigation are provided.
Mots-clé
Choroid plexuses, Internal dosimetry, Monte Carlo, RGD peptides
Pubmed
Web of science
Création de la notice
15/06/2018 16:45
Dernière modification de la notice
20/08/2019 13:10
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