Untargeted profiling of urinary steroid metabolites after testosterone ingestion: opening new perspectives for antidoping testing.

Détails

ID Serval
serval:BIB_2B44DB382204
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Untargeted profiling of urinary steroid metabolites after testosterone ingestion: opening new perspectives for antidoping testing.
Périodique
Bioanalysis
Auteur⸱e⸱s
Boccard J., Badoud F., Jan N., Nicoli R., Schweizer C., Pralong F., Veuthey J.L., Baume N., Rudaz S., Saugy M.
ISSN
1757-6199 (Electronic)
ISSN-L
1757-6180
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
6
Numéro
19
Pages
2523-2536
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
AIM: Antidoping procedures are expected to greatly benefit from untargeted metabolomic approaches through the discovery of new biomarkers of prohibited substances abuse.
RESULTS: Endogenous steroid metabolites were monitored in urine samples from a controlled elimination study of testosterone undecanoate after ingestion. A platform coupling ultra-high pressure LC with high-resolution quadrupole TOF MS was used and high between-subject metabolic variability was successfully handled using a multiblock data analysis strategy. Links between specific subsets of metabolites and influential genetic polymorphisms of the UGT2B17 enzyme were highlighted.
CONCLUSION: This exploratory metabolomic strategy constitutes a first step toward a better understanding of the underlying patterns driving the high interindividual variability of steroid metabolism. Promising biomarkers were selected for further targeted study.
Pubmed
Web of science
Création de la notice
27/11/2014 11:04
Dernière modification de la notice
20/08/2019 14:10
Données d'usage