Metabolic syndrome and the risk of breast cancer in postmenopausal women.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_2ACE28FBF3CC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Metabolic syndrome and the risk of breast cancer in postmenopausal women.
Périodique
Annals of Oncology
Auteur(s)
Rosato Valentina, Bosetti Cristina, Talamini Renato, Levi Fabio, Montella Maurizio, Giacosa Attilio, Negri Eva, La Vecchia Carlo
ISSN
1569-8041 (Electronic)
ISSN-L
0923-7534
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
22
Numéro
12
Pages
2687-2692
Langue
anglais
Résumé
BACKGROUND: Only a few small studies investigated the association between postmenopausal breast cancer and metabolic syndrome (MetS) as a single entity. Materials and methods: We analyzed the data of two Italian and Swiss case-control studies conducted between 1983 and 2007, including 3869 postmenopausal women with incident breast cancer and 4082 postmenopausal controls admitted to the same hospitals as cases for acute conditions. MetS was defined as the presence of at least three components among diabetes, drug-treated hypertension, drug-treated hyperlipidemia, and obesity. RESULTS: The odds ratios (ORs) of postmenopausal breast cancer were 1.33 [95% confidence interval (CI) 1.09-1.62] for diabetes, 1.19 (95% CI 1.07-1.33) for hypertension, 1.08 (95% CI 0.95-1.22) for hyperlipidemia, 1.26 (95% CI 1.11-1.44) for body mass index ≥30 kg/m(2), and 1.22 (95% CI 1.09-1.36) for waist circumference ≥88 cm. The risk of postmenopausal breast cancer was significantly increased for women with MetS (OR = 1.75, 95% CI 1.37-2.22, for three or more MetS components, P for trend for increasing number of components < 0.0001) and the risk was higher at older age (OR = 3.04, 95% CI 1.75-5.29, at age ≥70 years for three or more MetS components). CONCLUSIONS: This study supports a direct association between MetS and postmenopausal breast cancer risk.
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/05/2011 8:45
Dernière modification de la notice
20/08/2019 13:10
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