Retinale Vaskulopathie assoziiert mit Bergers IgA-Nephropathie. [Retinal vasculopathy associated with Berger's IgA nephropathy]

Détails

ID Serval
serval:BIB_2AC2D9A08E2E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Retinale Vaskulopathie assoziiert mit Bergers IgA-Nephropathie. [Retinal vasculopathy associated with Berger's IgA nephropathy]
Périodique
Klinische Monatsblatter fur Augenheilkunde
Auteur(s)
Wolfensberger  T. J., Piguet  B., Gregor  Z. J., Bird  A. C.
ISSN
0023-2165 (Print)
Statut éditorial
Publié
Date de publication
05/2000
Volume
216
Numéro
5
Pages
334-8
Notes
Case Reports
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
AIM: Ophthalmological complications associated with Berger's IgA nephropathy comprise scleritis, episcleritis, keratoconjunctivitis as well as anterior uveitis. We present a new association of IgA nephropathy with a retinal vasculopathy. METHODS: Presentation of two clinical cases. RESULTS: Two patients presented with hematuria and epistaxis associated with a retinal vasculopathy characterised by teleangiectasies, capillary occlusion with retinal hemorrhages, neovascularisations and macular edema with decreased visual acuity. Fluorescein angiography showed zones of non-perfusion as well as vasculitic changes. A general medical exam revealed a normal arterial pressure but a slightly elevated creatinine. Immunological investigations for the presence of antibodies showed no positive results. Renal biopsy demonstrated mesangial proliferations with diffuse deposits of IgA. Over the course of a 2 year follow-up some of the retinal changes regressed under treatment with cortisone and visual acuity returned to normal. The teleangiectasies showed no progression. CONCLUSION: Berger's IgA nephropathy can be associated with a retinal vasculopathy which may be due to local deposition of IgA immune complexes in the retinal vessels.
Mots-clé
Adult Antigen-Antibody Complex/immunology Edema/immunology Fluorescein Angiography Glomerulonephritis, IGA/*complications/immunology Humans Immune Complex Diseases/complications Immunoglobulin A/immunology Male Retinal Diseases/*diagnosis/etiology/*immunology Retinal Hemorrhage/immunology Retinal Neovascularization/immunology Retinal Vessels/*pathology Telangiectasis/immunology Visual Acuity/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 13:05
Dernière modification de la notice
20/08/2019 13:10
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