Respiratory depression by midazolam and diazepam

Détails

ID Serval
serval:BIB_2AB44B9BAD81
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Respiratory depression by midazolam and diazepam
Périodique
Anesthesiology
Auteur(s)
Forster  A., Gardaz  J. P., Suter  P. M., Gemperle  M.
ISSN
0003-3022 (Print)
Statut éditorial
Publié
Date de publication
12/1980
Volume
53
Numéro
6
Pages
494-7
Notes
Journal Article --- Old month value: Dec
Résumé
The purpose of this study was to examine the respiratory depression produced by diazepam and by midazolam. Ventilatory and mouth occlusion pressure responses to CO2 were measured in eight healthy volunteers before and after the intravenous administration of 0.3 mg/kg of diazepam and 0.15 mg/kg of midazolam. The mean ventilatory response to CO2 (mean +/- SEM) decreased after administration of diazepam or midazolam from 2.0 +/- 0.2 to 1.3 +/- 0.1 1.min-1/torr or from 2.1 +/- 0.2 to 1.4 +/- 0.1 1.min-1/torr, respectively. In the same volunteers, the mouth occlusion pressure responses decreased from 0.54 +/- 0.05 to 0.30 +/- 0.04 cm H2O/torr after midazolam and from 0.67 +/- 0.12 to 0.28 +/- 0.07 cm H2O/torr after diazepam. When compared with the control slopes of the ventilatory and mouth occlusion pressure responses, the drug slopes were significantly different. Respiration was similarly depressed after diazepam and after midazolam. That both the ventilatory and mouth occlusion pressure responses to CO2 are equally depressed by intravenous injections of midazolam and of diazepam at equipotent doses suggests a direct depression of the central respiratory drive by these drugs.
Mots-clé
Adult Airway Obstruction/etiology Benzodiazepines/*pharmacology Diazepam/adverse effects/*pharmacology Female Humans Male Midazolam Phlebitis/chemically induced Respiration/*drug effects
Pubmed
Web of science
Création de la notice
28/01/2008 10:48
Dernière modification de la notice
20/08/2019 13:10
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