Gut Microbiota, Immune System, and Bone.

Détails

ID Serval
serval:BIB_2AA8980D7B66
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Gut Microbiota, Immune System, and Bone.
Périodique
Calcified tissue international
Auteur⸱e⸱s
D'Amelio P., Sassi F.
ISSN
1432-0827 (Electronic)
ISSN-L
0171-967X
Statut éditorial
Publié
Date de publication
04/2018
Peer-reviewed
Oui
Volume
102
Numéro
4
Pages
415-425
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The gut microbiota (GM) is the whole of commensal, symbiotic, and pathogenic microorganisms living in our intestine. The GM-host interactions contribute to the maturation of the host immune system, modulating its systemic response. It is well documented that GM can interact with non-enteral cells such as immune cells, dendritic cells, and hepatocytes, producing molecules such as short-chain fatty acids, indole derivatives, polyamines, and secondary bile acid. The receptors for some of these molecules are expressed on immune cells, and modulate the differentiation of T effector and regulatory cells: this is the reason why dysbiosis is correlated with several autoimmune, metabolic, and neurodegenerative diseases. Due to the close interplay between immune and bone cells, GM has a central role in maintaining bone health and influences bone turnover and density. GM can improve bone health also increasing calcium absorption and modulating the production of gut serotonin, a molecule that interacts with bone cells and has been suggested to act as a bone mass regulator. Thus, GM manipulation by consumption of antibiotics, changes in dietary habits, and the use of pre- and probiotics may affect bone health. This review summarizes evidences on the influence of GM on immune system and on bone turnover and density and how GM manipulation may influence bone health.
Mots-clé
Animals, Bone Density/immunology, Bone and Bones/immunology, Bone and Bones/microbiology, Dysbiosis/immunology, Gastrointestinal Microbiome/immunology, Humans, Immune System/microbiology, Intestines/immunology, Intestines/microbiology, Bone, Gut microbiota, Immune system, Inflammation, Osteoporosis, Probiotics
Pubmed
Web of science
Création de la notice
13/01/2020 15:45
Dernière modification de la notice
14/01/2020 6:26
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