"Doughnut" technetium pyrophosphate myocardial scintigrams. A marker of severe left ventricular dysfunction

Détails

ID Serval
serval:BIB_2A9AC858CE65
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
"Doughnut" technetium pyrophosphate myocardial scintigrams. A marker of severe left ventricular dysfunction
Périodique
Clinical Nuclear Medicine
Auteur(s)
Nicod  P., Corbett  J. R., Rude  R. E., Dehmer  G. J., Smucker  M., Buja  L. M., Parkey  R. W., Lewis  S. E., Willerson  J. T.
ISSN
0363-9762 (Print)
Statut éditorial
Publié
Date de publication
10/1982
Volume
7
Numéro
10
Pages
447-53
Notes
Case Reports
Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Résumé
The "doughnut" pattern on Tc-99m pyrophosphate (PPi) myocardial scintigraphy is characterized by a border of tracer uptake surrounding a central zone of relatively decreased activity. This pattern is generally associated with large transmural anterior myocardial infarcts (MI) caused by occlusion or critical stenosis of the left anterior descending coronary artery. Such infarcts typically involve a significant portion of the anterior wall and are associated with a complicated clinical course and poor prognosis. In order to evaluate the relationship between the presence of the doughnut pattern and left ventricular (LV) function, radionuclide ventriculography was performed within 15 days after infarction in 58 patients with transmural anterior MI. In patients without previous MI, 15/38 (39.5%) had doughnut scintigrams. These patients demonstrated significant reductions in LV ejection fraction (EF) (28 +/- 10% versus 45 +/- 12%, P less than 0.001) and normalized LV wall motion scores (29 +/- 11% versus 61 +/- 10%, P less than 0.001) when compared with patients with "nondoughnut" scintigrams. Patients with doughnut scintigrams had a significantly greater incidence of severe septal hypokinesis (P less than 0.001) and apical dyskinesis (P less than 0.03). LV end-systolic volumes were also larger in the patients with doughnut scintigrams (73 +/- 32 ml versus 40 +/- 17 mI/M2, P less than 0.005). In contrast, there was no significant difference in LVEF, normalized LV wall motion score, or LV volumes between doughnut and nondoughnut groups in patients with previous MI.
Mots-clé
Diphosphates/*diagnostic use Female Heart Ventricles/physiopathology/*radionuclide imaging Humans Male Middle Aged Myocardial Infarction/pathology/*radionuclide imaging Myocardium/pathology Prognosis Recurrence Stroke Volume Technetium/*diagnostic use Technetium Tc 99m Pyrophosphate Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 14:00
Dernière modification de la notice
20/08/2019 13:10
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