Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.

Détails

ID Serval
serval:BIB_2A747BDB030E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.
Périodique
Developmental Cell
Auteur(s)
Sabine A., Agalarov Y., Maby-El Hajjami H., Jaquet M., Hägerling R., Pollmann C., Bebber D., Pfenniger A., Miura N., Dormond O., Calmes J.M., Adams R.H., Mäkinen T., Kiefer F., Kwak B.R., Petrova T.V.
ISSN
1878-1551 (Electronic)
ISSN-L
1534-5807
Statut éditorial
Publié
Date de publication
2012
Volume
22
Numéro
2
Pages
430-445
Langue
anglais
Résumé
Lymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early lymphatic-valve morphogenesis and the role of biomechanical forces are not well understood. We found that the transcription factors PROX1 and FOXC2, highly expressed from the onset of valve formation, mediate segregation of lymphatic-valve-forming cells and cell mechanosensory responses to shear stress in vitro. Mechanistically, PROX1, FOXC2, and flow coordinately control expression of the gap junction protein connexin37 and activation of calcineurin/NFAT signaling. Connexin37 and calcineurin are required for the assembly and delimitation of lymphatic valve territory during development and for its postnatal maintenance. We propose a model in which regionally increased levels/activation states of transcription factors cooperate with mechanotransduction to induce a discrete cell-signaling pattern and morphogenetic event, such as formation of lymphatic valves. Our results also provide molecular insights into the role of endothelial cell identity in the regulation of vascular mechanotransduction.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/04/2012 14:14
Dernière modification de la notice
20/08/2019 13:10
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