Risk Factors for Anal Cancer in Persons Infected With HIV: A Nested Case-Control Study in the Swiss HIV Cohort Study.

Détails

ID Serval
serval:BIB_29F9A91DE840
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Risk Factors for Anal Cancer in Persons Infected With HIV: A Nested Case-Control Study in the Swiss HIV Cohort Study.
Périodique
American Journal of Epidemiology
Auteur⸱e⸱s
Bertisch B., Franceschi S., Lise M., Vernazza P., Keiser O., Schöni-Affolter F., Bouchardy C., Dehler S., Levi F., Jundt G., Ess S., Pawlita M., Kovari H., Wandeler G., Calmy A., Cavassini M., Stöckle M. , Clifford G.
Collaborateur⸱rice⸱s
Swiss HIV Cohort Study Investigators
ISSN
1476-6256 (Electronic)
ISSN-L
0002-9262
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
178
Numéro
6
Pages
877-884
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Although persons infected with human immunodeficiency virus (HIV), particularly men who have sex with men, are at excess risk for anal cancer, it has been difficult to disentangle the influences of anal exposure to human papillomavirus (HPV) infection, immunodeficiency, and combined antiretroviral therapy. A case-control study that included 59 anal cancer cases and 295 individually matched controls was nested in the Swiss HIV Cohort Study (1988-2011). In a subset of 41 cases and 114 controls, HPV antibodies were tested. A majority of anal cancer cases (73%) were men who have sex with men. Current smoking was significantly associated with anal cancer (odds ratio (OR) = 2.59, 95% confidence interval (CI): 1.25, 5.34), as were antibodies against L1 (OR = 4.52, 95% CI: 2.00, 10.20) and E6 (OR = â^?, 95% CI: 4.64, â^?) of HPV16, as well as low CD4+ cell counts, whether measured at nadir (OR per 100-cell/μL decrease = 1.53, 95% CI: 1.18, 2.00) or at cancer diagnosis (OR per 100-cell/μL decrease = 1.24, 95% CI: 1.08, 1.42). However, the influence of CD4+ cell counts appeared to be strongest 6-7 years prior to anal cancer diagnosis (OR for <200 vs. â0/00¥500 cells/μL = 14.0, 95% CI: 3.85, 50.9). Smoking cessation and avoidance of even moderate levels of immunosuppression appear to be important in reducing long-term anal cancer risks.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/09/2013 19:36
Dernière modification de la notice
20/08/2019 13:09
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