E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.

Détails

ID Serval
serval:BIB_2975DD6C3433
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.
Périodique
Molecular Cell
Auteur⸱e⸱s
Tyagi S., Chabes A.L., Wysocka J., Herr W.
ISSN
1097-2765[print], 1097-2765[linking]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
27
Numéro
1
Pages
107-119
Langue
anglais
Résumé
E2F transcriptional regulators control human-cell proliferation by repressing and activating the transcription of genes required for cell-cycle progression, particularly the S phase. E2F proteins repress transcription in association with retinoblastoma pocket proteins, but less is known about how they activate transcription. Here, we show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in insect cells. Human HCF-1-E2F interactions are versatile: their associations and binding to E2F-responsive promoters are cell-cycle selective, and HCF-1 displays coactivator properties when bound to the E2F1 activator and corepressor properties when bound to the E2F4 repressor. During the G1-to-S phase transition, HCF-1 recruits the mixed-lineage leukemia (MLL) and Set-1 histone H3 lysine 4 methyltransferases to E2F-responsive promoters and induces histone methylation and transcriptional activation. These results suggest that HCF-1 induces cell-cycle-specific transcriptional activation by E2F proteins to promote cell proliferation.
Mots-clé
Amino Acid Sequence, Conserved Sequence, E2F Transcription Factors/chemistry, E2F Transcription Factors/metabolism, Evolution, Molecular, G1 Phase, Hela Cells, Histone Deacetylases/metabolism, Histone-Lysine N-Methyltransferase/metabolism, Host Cell Factor C1/metabolism, Humans, Lysine/metabolism, Molecular Sequence Data, Myeloid-Lymphoid Leukemia Protein/metabolism, Promoter Regions, Genetic/genetics, Protein Binding, Protein Structure, Tertiary, Repressor Proteins/metabolism, Retinoblastoma Protein/metabolism, Retinoblastoma-Like Protein p130/metabolism, S Phase/genetics, Sin3 Histone Deacetylase and Corepressor Complex, Two-Hybrid System Techniques
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:36
Dernière modification de la notice
20/08/2019 13:09
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