Fine-Tuning Tumor Endothelial Cells to Selectively Kill Cancer.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_294BEB9B0137
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Fine-Tuning Tumor Endothelial Cells to Selectively Kill Cancer.
Périodique
International journal of molecular sciences
Auteur(s)
Uldry E., Faes S., Demartines N., Dormond O.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Statut éditorial
Publié
Date de publication
30/06/2017
Peer-reviewed
Oui
Volume
18
Numéro
7
Pages
1-16
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Tumor endothelial cells regulate several aspects of tumor biology, from delivering oxygen and nutrients to shaping the immune response against a tumor and providing a barrier against tumor cell dissemination. Accordingly, targeting tumor endothelial cells represents an important modality in cancer therapy. Whereas initial anti-angiogenic treatments focused mainly on blocking the formation of new blood vessels in cancer, emerging strategies are specifically influencing certain aspects of tumor endothelial cells. For instance, efforts are generated to normalize tumor blood vessels in order to improve tumor perfusion and ameliorate the outcome of chemo-, radio-, and immunotherapy. In addition, treatment options that enhance the properties of tumor blood vessels that support a host's anti-tumor immune response are being explored. Hence, upcoming anti-angiogenic strategies will shape some specific aspects of the tumor blood vessels that are no longer limited to abrogating angiogenesis. In this review, we enumerate approaches that target tumor endothelial cells to provide anti-cancer benefits and discuss their therapeutic potential.

Mots-clé
Animals, Endothelial Cells/drug effects, Endothelial Cells/metabolism, Humans, Immunotherapy, Neoplasms/drug therapy, Neoplasms/therapy, Neovascularization, Pathologic/drug therapy, Neovascularization, Pathologic/therapy, angiogenesis, cancer, endothelial cell, therapies
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/07/2017 13:50
Dernière modification de la notice
20/08/2019 14:08
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