Trials in isolated systolic hypertension: an update.

Détails

ID Serval
serval:BIB_29191
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Trials in isolated systolic hypertension: an update.
Périodique
Current Cardiology Reports
Auteur⸱e⸱s
Waeber B.
ISSN
1523-3782 (Print)
ISSN-L
1523-3782
Statut éditorial
Publié
Date de publication
2003
Volume
5
Numéro
6
Pages
427-434
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Isolated systolic hypertension (ISH) has proved to be a powerful predisposing factor for cardiovascular diseases in the elderly. Recent placebo-controlled interventional trials such as the Systolic Hypertension in the Elderly Program, the Systolic Hypertension in Europe, and the Systolic Hypertension in China showed that the lowering of systolic blood pressure using a diuretic- or a calcium antagonist-based treatment is associated with a decrease in cardiovascular events. Antihypertensive therapy was found especially effective in preventing stroke in the elderly with ISH. A slowing in the progression of dementia was observed in patients randomized to a calcium antagonist-based treatment. Patients at high cardiovascular risk such as those with diabetes benefited the most from treatment. In another trial performed in patients with left ventricular hypertrophy (Losartan Intervention For Endpoint Reduction), a subset of patients had ISH. In those patients, an angiotensin II antagonist-based treatment was superior to a b-blocker-based treatment in preventing cardiovascular complications. The experience accumulated in patients with ISH showed that combination therapy is often required to control blood pressure. Overall, the evidence available today indicates that pharmacologic treatment of ISH markedly improves the outcome of elderly patients.
Mots-clé
Aged, Antihypertensive Agents/therapeutic use, Cardiovascular Diseases/etiology, Cardiovascular Diseases/prevention & control, Humans, Hypertension/complications, Hypertension/drug therapy, Randomized Controlled Trials as Topic
Pubmed
Création de la notice
19/11/2007 13:26
Dernière modification de la notice
20/08/2019 14:08
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