MYC regulation of a "poor-prognosis" metastatic cancer cell state.

Détails

ID Serval
serval:BIB_2910E0DA4029
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
MYC regulation of a "poor-prognosis" metastatic cancer cell state.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Wolfer A., Wittner B.S., Irimia D., Flavin R.J., Lupien M., Gunawardane R.N., Meyer C.A., Lightcap E.S., Tamayo P., Mesirov J.P., Liu X.S., Shioda T., Toner M., Loda M., Brown M., Brugge J.S., Ramaswamy S.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2010
Volume
107
Numéro
8
Pages
3698-3703
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Résumé
Gene expression signatures are used in the clinic as prognostic tools to determine the risk of individual patients with localized breast tumors developing distant metastasis. We lack a clear understanding, however, of whether these correlative biomarkers link to a common biological network that regulates metastasis. We find that the c-MYC oncoprotein coordinately regulates the expression of 13 different "poor-outcome" cancer signatures. In addition, functional inactivation of MYC in human breast cancer cells specifically inhibits distant metastasis in vivo and invasive behavior in vitro of these cells. These results suggest that MYC oncogene activity (as marked by "poor-prognosis" signature expression) may be necessary for the translocation of poor-outcome human breast tumors to distant sites.
Mots-clé
Breast Neoplasms/genetics, Breast Neoplasms/pathology, Cell Movement/genetics, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Metastasis, Oligonucleotide Array Sequence Analysis, Prognosis, Proto-Oncogene Proteins c-myc/metabolism, Tumor Markers, Biological/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/02/2012 15:13
Dernière modification de la notice
20/08/2019 14:08
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