Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.

Détails

ID Serval
serval:BIB_2900C83E1AC7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
Périodique
Virology
Auteur(s)
Georgel P., Jiang Z., Kunz S., Janssen E., Mols J., Hoebe K., Bahram S., Oldstone M.B., Beutler B.
ISSN
0042-6822 (Print)
ISSN-L
0042-6822
Statut éditorial
Publié
Date de publication
2007
Volume
362
Numéro
2
Pages
304-313
Langue
anglais
Résumé
We have previously shown that mutations of CD14 or TLR4 impair type I interferon (IFN) production and macrophage survival during infection with vesicular stomatitis virus (VSV). We now report that VSV glycoprotein G (gpG) is essential for the induction of a previously unrecognized CD14/TLR4-dependent response pathway in which the adapter TRAM has predominant importance, absent any need for MyD88 or Mal, and with only a partial requirement for TRIF. Downstream of TRAM, IRF7 activation leads to a type I IFN response. The pathway is utilized by myeloid dendritic cells (mDCs) and macrophages rather than plasmacytoid DCs. This new mode of TLR4 signal transduction, which does not stimulate NF-kappaB activation, reveals the importance of viral protein recognition by mDCs and shows that TLR4 can drive qualitatively different events within the cell in response to different ligands.
Mots-clé
Adaptor Proteins, Vesicular Transport/immunology, Animals, Cell Line, Cell Survival, Dendritic Cells/immunology, Female, Gene Expression Regulation, Humans, Interferon Regulatory Factor-7/biosynthesis, Interferon Type I/biosynthesis, Macrophages, Peritoneal/virology, Male, Membrane Glycoproteins/immunology, Membrane Transport Proteins/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Myelin Proteins/immunology, Myelin and Lymphocyte-Associated Proteolipid Proteins, Myeloid Differentiation Factor 88/immunology, Proteolipids/immunology, RNA, Messenger/biosynthesis, Receptors, Interleukin/immunology, Signal Transduction, Toll-Like Receptor 4/immunology, Toll-Like Receptor 4/metabolism, Vesicular stomatitis Indiana virus/immunology, Viral Envelope Proteins/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/04/2013 12:56
Dernière modification de la notice
20/08/2019 14:08
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