Chronic bradykinin receptor blockade modulates neonatal renal function.

Détails

ID Serval
serval:BIB_28E1B090A6F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Chronic bradykinin receptor blockade modulates neonatal renal function.
Périodique
Biology of the Neonate
Auteur(s)
Tóth-Heyn P., Mosig D., Guignard J.P.
ISSN
0006-3126
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
77
Numéro
1
Pages
45-49
Langue
anglais
Résumé
Recent data indicate that bradykinin participates in the regulation of neonatal glomerular function and also acts as a growth regulator during renal development. The aim of the present study was to investigate the involvement of bradykinin in the maturation of renal function. Bradykinin beta2-receptors of newborn rabbits were inhibited for 4 days by Hoe 140. The animals were treated with 300 microg/kg s.c. Hoe 140 (group Hoe, n = 8) or 0.9% NaCl (group control, n = 8) twice daily. Clearance studies were performed in anesthetized rabbits at the age of 8-9 days. Bradykinin receptor blockade did not impair kidney growth, as demonstrated by similar kidney weights in the two groups, nor did it influence blood pressure. Renal blood flow was higher, while renal vascular resistance and filtration fraction were lower in Hoe 140-treated rabbits. No difference in glomerular filtration rate was observed. The unexpectedly higher renal perfusion observed in group Hoe cannot be explained by the blockade of the known vasodilator and trophic effect of bradykinin. Our results indicate that in intact kallikrein-kinin system is necessary for the normal functional development of the kidney.
Mots-clé
Adrenergic beta-Antagonists/pharmacology, Animals, Animals, Newborn, Blood Gas Analysis, Bradykinin/analogs & derivatives, Bradykinin/pharmacology, Cardiovascular Agents/pharmacology, Cardiovascular Agents/urine, Hematocrit, Indoles/pharmacology, Indoles/urine, Inulin/pharmacology, Inulin/urine, Kidney/growth & development, Kidney/physiology, Rabbits, Receptors, Bradykinin/antagonists & inhibitors, Receptors, Bradykinin/physiology, Urine/chemistry, p-Aminohippuric Acid/pharmacology, p-Aminohippuric Acid/urine
Pubmed
Web of science
Création de la notice
17/07/2009 17:20
Dernière modification de la notice
20/08/2019 14:08
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