REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_28C3B95207AF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6.
Périodique
Biology open
Auteur(s)
Chavan R., Preitner N., Okabe T., Strittmatter L.M., Xu C., Ripperger J.A., Pitteloud N., Albrecht U.
ISSN-L
2046-6390
Statut éditorial
Publié
Date de publication
15/01/2017
Peer-reviewed
Oui
Volume
6
Numéro
1
Pages
1-7
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21.

Pubmed
Web of science
Open Access
Oui
Création de la notice
06/03/2017 19:15
Dernière modification de la notice
20/08/2019 14:08
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