Apical drive-A cellular mechanism of dreaming?
Détails
ID Serval
serval:BIB_28ADC9143FE5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Apical drive-A cellular mechanism of dreaming?
Périodique
Neuroscience and biobehavioral reviews
ISSN
1873-7528 (Electronic)
ISSN-L
0149-7634
Statut éditorial
Publié
Date de publication
12/2020
Peer-reviewed
Oui
Volume
119
Pages
440-455
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Dreams are internally generated experiences that occur independently of current sensory input. Here we argue, based on cortical anatomy and function, that dream experiences are tightly related to the workings of a specific part of cortical pyramidal neurons, the apical integration zone (AIZ). The AIZ receives and processes contextual information from diverse sources and could constitute a major switch point for transitioning from externally to internally generated experiences such as dreams. We propose that during dreams the output of certain pyramidal neurons is mainly driven by input into the AIZ. We call this mode of functioning "apical drive". Our hypothesis is based on the evidence that the cholinergic and adrenergic arousal systems, which show different dynamics between waking, slow wave sleep, and rapid eye movement sleep, have specific effects on the AIZ. We suggest that apical drive may also contribute to waking experiences, such as mental imagery. Future studies, investigating the different modes of apical function and their regulation during sleep and wakefulness are likely to be richly rewarded.
Mots-clé
Achetylcholine, Dendrites, Dreaming, Noradrenaline, Pyramidal neurons, Sleep, Acetylcholine, Norepinephrine
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/09/2020 9:43
Dernière modification de la notice
14/01/2021 7:22