Neighbourhood socioeconomic deprivation and allostatic load: a multi-cohort study.

Détails

Ressource 1Télécharger: BIB_289CEBCDE0D2.pdf (1390.48 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_289CEBCDE0D2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Neighbourhood socioeconomic deprivation and allostatic load: a multi-cohort study.
Périodique
Scientific reports
Auteur⸱e⸱s
Ribeiro A.I., Fraga S., Kelly-Irving M., Delpierre C., Stringhini S., Kivimaki M., Joost S., Guessous I., Gandini M., Vineis P., Barros H.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
19/06/2019
Peer-reviewed
Oui
Volume
9
Numéro
1
Pages
8790
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Living in deprived neighbourhoods may have biological consequences, but few studies have assessed this empirically. We examined the association between neighbourhood deprivation and allostatic load, a biological marker of wear and tear, taking into account individual's socioeconomic position. We analysed data from three cohort studies (CoLaus-Switzerland; EPIPorto-Portugal; Whitehall II-UK) comprising 16,364 participants. We defined allostatic load using ten biomarkers of dysregulated metabolic, cardiovascular, and inflammatory systems (body mass index; waist circumference; total, high and low density lipoprotein cholesterol; triglycerides; glucose; systolic and diastolic blood pressure; C-reactive protein). Mixed Poisson regression models were fitted to examine associations with neighbourhood deprivation (in quintiles, Q1-least deprived as reference). After adjustment for confounding variables, participants living in the most deprived quintile had 1.13 times higher allostatic load than those living in the least deprived quintile (Relative Risk, RR, for Q2 RR = 1.06, 95% CI 1.03-1.09; Q3 = 1.06, 1.03-1.10; Q4 = 1.09, 1.06-1.12; Q5 = 1.13, 1.09-1.16). This association was partially modified by individual's socioeconomic position, such that the relative risk was higher in participants with low socioeconomic position (Q5 vs Q1 1.16, 1.11-1.22) than those with high socioeconomic position (Q5 vs Q1 1.07, 1.01-1.13). Neighbourhood deprivation is associated with biological wear and tear, suggesting that neighbourhood-level interventions may yield health gains.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/06/2019 17:05
Dernière modification de la notice
20/08/2019 14:08
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