Sorting out the cognitive implications of vascular lesions in the aging brain

Détails

ID Serval
serval:BIB_2896B512F67A
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Sorting out the cognitive implications of vascular lesions in the aging brain
Auteur⸱e⸱s
Gold Gabriel, Kövari Enikö, Herrmann François R., Canuto Alessandra, Hof Patrick R., Michel Jean-Pierre, Bouras Constantin, Giannakopoulos Panteleimon
ISBN
0197-4580
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
27
Série
Neurobiology of Aging
Pages
9
Langue
anglais
Notes
SAPHIRID:61501
Résumé
Vascular lesions are particularly common in aged brain. However, it is still unclear whether all such lesions affect cognition. Methodological problems: masking effect of concomitant pathologies, heterogeneity of cerebral vascular lesions, highly variable location and lack of a clear cut pathologic correlate of certain neuroradiological findings may explain discrepancies among published studies. In order to better explore relationships between specific characteristics of vascular lesions (type, size and location) and cognitive status we performed several clinicopathological studies in relatively "pure" series of autopsied elderly individuals with varying levels of cognitive impairment. Cognitive status was classified according to the Clinical Dementia Rating (CDR) scale and neuropathological evaluation included A_-protein deposition and neurofibrillary tangle staging and bilateral semiquantitative assessment of ischemic lesions. In a first series of 45 cases without significant neurofibrillary tangle pathology or macrovascular lesions, we report that cortical microinfarcts explained 36.1% of the variability in CDR, in contrast to focal cortical and white matter gliosis, which were not significantly associated with CDR. In a second series of 72 cases without significant neurofibrillary tangle pathology and without macroscopic ischemic lesions other than lacunes, we found that basal ganglia and thalamic lacunes, periventricular and diffuse white matter demylelination explained 6%, 5%, 6% and 6% of the CDR variability, respectively. Lacunes in the frontal, temporal and parietal deep white matter did not correlate with cognitive decline in this series. Microscopic ischemic pathology, basal ganglia and thalamic lacunes and both diffuse and periventricual demyelination should be taken into account for the elaboration of future neuropathological criteria for vascular and mixed dementia.
Création de la notice
10/03/2008 12:04
Dernière modification de la notice
20/08/2019 14:08
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