Blunted glucose-induced thermogenesis in 'overweight' patients: a factor contributing to relapse of obesity.

Détails

ID Serval
serval:BIB_287A18AEE1FE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Blunted glucose-induced thermogenesis in 'overweight' patients: a factor contributing to relapse of obesity.
Périodique
International Journal of Obesity
Auteur⸱e⸱s
Golay A., Schutz Y., Felber J.P., Jallut D., Jéquier E.
ISSN
0307-0565 (Print)
ISSN-L
0307-0565
Statut éditorial
Publié
Date de publication
1989
Volume
13
Numéro
6
Pages
767-775
Langue
anglais
Résumé
Glucose-induced thermogenesis was studied in 12 overweight patients (9F and 3M) before (mean body weight +/- s.e.m. 83 +/- 2 kg) and after weight loss (68 +/- 2 kg), and in eight of the same patients following relapse of body weight gain (84 +/- 5 kg). Expressed as a percentage of the energy content of the 100 g oral glucose load, glucose-induced thermogenesis was lower in the overweight before weight loss (6.5 +/- 0.5 per cent, P less than 0.05), after weight loss (3.9 +/- 0.6 per cent, P less than 0.01) and after weight regain (6.3 +/- 0.9 per cent, P less than 0.05) than in a group of lean control subjects, matched for sex and age (8.3 +/- 0.5 per cent). Basal energy expenditure was lower after weight reduction than before (1.16 +/- 0.04 vs 1.41 +/- 0.08 kcal/min, P less than 0.01). In the formerly overweight patients, the combined effect of a decreased basal energy expenditure and an attenuation of glucose induced thermogenesis resulted in a postprandial energy expenditure which was markedly lower than in the overweight state (P less than 0.001). Following relapse of obesity, glucose-induced thermogenesis remained attenuated compared to control subjects. These results suggest that a lowered basal energy expenditure and a reduced glucose-induced thermogenesis contribute to the positive energy balance which results in relapse of body weight gain after cessation of a hypocaloric diet.
Mots-clé
Adult, Blood Glucose/metabolism, Energy Metabolism/physiology, Female, Humans, Male, Obesity/metabolism, Recurrence, Weight Loss/physiology
Pubmed
Web of science
Création de la notice
21/01/2008 14:07
Dernière modification de la notice
20/08/2019 14:07
Données d'usage