Propylene glycol monomethyl ether occupational exposure (PGME). 4. Analysis of 2-methoxypropionic acid in urine.

Détails

ID Serval
serval:BIB_28732
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Propylene glycol monomethyl ether occupational exposure (PGME). 4. Analysis of 2-methoxypropionic acid in urine.
Périodique
International Archives of Occupational and Environmental Health
Auteur⸱e⸱s
Devanthéry A., Berode M., Droz P.O., Pulkkinen J.
ISSN
0340-0131
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
76
Numéro
2
Pages
151-155
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
OBJECTIVE: The two isomers propylene glycol monomethyl ether [PGME-alpha (1-methoxy-2-propanol, M2P) and PGME-beta (2-methoxy-1-propanol)] have different toxicities due to the different ways they are metabolised. The higher toxicity of PGME-beta has been attributed to the formation of 2-methoxypropionic acid (2-MPA) as a metabolite of primary alcohol. Six healthy male volunteers were exposed to PGME-alpha vapour (15, 50 and 95 ppm) with and without respiratory protection for 6 h, including a 30-min break. They were also exposed to PGME-alpha liquid (10% or 30% in water), via one hand, for 30 min or 1 h. Commercial products of M2P always contain a small quantity of the beta isomer, and GC analysis has shown that the product used for this human volunteer exposure contained approximately 0.3% of the beta isomer. The objective of this study was to determine the levels of 2-MPA in urine after these exposures to 99.7% PGME-alpha. METHOD: An analytical method developed by Laitinen [6] was used for the determination of 2-MPA in the urine of exposed volunteers. RESULTS: End exposure levels of 2-MPA were found to reach from 1.19 to 3.29 mg/l for inhalation and dermal exposure to PGME-alpha vapour and from under the detection limit to 2.10 mg/l for exposure of one hand in PGME-alpha liquid. 2-MPA concentrations in urine samples from a non-exposed person or from a person exposed to PGME-alpha vapour at 15 ppm (inhalation and dermal exposure) and also from a person exposed to PGME-alpha vapour up to 95 ppm with respiratory protection (dermal-only exposure) all varied from under the detection limit to 0.30 mg/l and are then not significant.
Mots-clé
Adult, Breath Tests, Chromatography, Gas, Humans, Inhalation Exposure, Male, Occupational Exposure, Propionic Acids
Pubmed
Web of science
Création de la notice
19/11/2007 12:26
Dernière modification de la notice
20/08/2019 13:07
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