Candida albicans is a very common fungal pathogen and a member of the normal flora, as it colonizes gastro-intestinal tract and mucosal surfaces. If harmless the majority of time, this fungus can cause various diseases to vulnerable or healthy hosts such as oropharyngeal candidiasis, vulvovaginal candidiasis, congenital mucocutaneous candidiasis, invasive candidiasis and superficial skin mycoses. The treatment of all those conditions are antifungal drugs. To impact its hosts, C. albicans possesses a wide range of virulence factors and abilities improving pathogenicity such as yeast to hyphal transition, biofilm formation, many adhesins allowing to initiate, keep contact and invade hosts, secreted products and white to gray to opaque transition, mating form conferring further adaptation capacities. The adhesion forces between C. albicans and host epithelial cells play a major role in the pathogenicity of this organism. To quantify these interaction forces we used an atomic force microscope (AFM). C. albicans yeast cell were attached to the apex of a tip less cantilever and set it in contact with keratinocytes cells in way to measure adhesion forces and recorded force-distance curves. Seven C. albicans strains (CEC3675, 3686, 4497, 5314, 3685, 3761, 3634) have been tested for their adhesion capacity to keratinocytes (TR 146 cells). Results show that adhesion forces distribution range between 0.1-4 nN with adhesion work inferior to 12.3 fJ. CEC3634, 3685, 3686, 5314 and 3765 appear to be more adhesive than 4497 and 3675. Those results are coherent with results obtained by other techniques, which is very encouraging.