In this issue.

Détails

ID Serval
serval:BIB_27D83A017EC7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
In this issue.
Périodique
Virchows Archiv
Auteur⸱e⸱s
Bosman F.T.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Statut éditorial
Publié
Date de publication
2015
Volume
466
Numéro
4
Pages
361
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
A new issue, once again a bouquet of attractive papers. First of all the paper by Droit-Dupré et al. (10.1007/s00428-015-1724-9). The group studied colonic adenocarcinomas, not otherwise specified, by immunohistochemistry for the expression of markers of intestinal epithelial cell differentiation. Hierarchical clustering analysis identified a major cluster of two thirds of the case series, expressing cytokeratin 20, CDX2 and MUC2 and invariably mismatch repair competent, which they called crypt-like. In stage III colon cancer, the crypt-like cluster had a better prognosis. The paper is a relatively simple example of what is happening in cancer classification beyond morphology: multiparameter differentiation and (epi)genomic markers defining new subtypes of cancer with potential clinical significance in clinical decision making.
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/03/2015 9:04
Dernière modification de la notice
20/08/2019 13:07
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