Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome.

Détails

ID Serval
serval:BIB_27AECC92A188
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome.
Périodique
Expert Opinion on Therapeutic Targets
Auteur(s)
Tan C.K., Zhuang Y., Wahli W.
ISSN
1744-7631 (Electronic)
ISSN-L
1472-8222
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
21
Numéro
3
Pages
333-348
Langue
anglais
Résumé
Peroxisome proliferator-activated receptors (PPARs) are the molecular targets of hypolipidemic and insulin-sensitizing drugs and implicated in a multitude of processes that fine-tune the functions of all organs in vertebrates. As transcription factors they sense endogenous and exogenous lipid signaling molecules and convert these signals into intricate gene responses that impact health and disease. The PPARs act as modulators of cellular, organ, and systemic processes, such as lipid and carbohydrate metabolism, making them valuable for understanding body homeostasis influenced by nutrition and exercise. Areas covered: This review concentrates on synthetic and natural PPAR ligands and how they have helped reveal many aspects of the transcriptional control of complex processes important in health. Expert opinion: The three PPARs have complementary roles in the fine-tuning of most fundamental body functions, especially energy metabolism. Understanding their inter-relatedness using ligands that simultaneously modulate the activity of more than one of these receptors is a major goal. This approach may provide essential knowledge for the development of dual or pan-PPAR agonists or antagonists as potential new health-promoting agents and for nutritional approaches to prevent metabolic diseases.

Mots-clé
Agonists, insulin resistance, lipid metabolism, metabolic syndrome, PPARs, type 2 diabetes, phytochemicals
Pubmed
Web of science
Création de la notice
24/01/2017 19:06
Dernière modification de la notice
20/08/2019 14:06
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