Immunogenicity and reactogenicity of a combined hepatitis A and B vaccine in healthy Chilean subjects

Détails

ID Serval
serval:BIB_2793F8BA0AFA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Immunogenicity and reactogenicity of a combined hepatitis A and B vaccine in healthy Chilean subjects
Périodique
International Journal of Infectious Diseases
Auteur⸱e⸱s
Prado  V., Riedemann  S., Ibarra  H., Potin  M.
ISSN
1201-9712 (Print)
Statut éditorial
Publié
Date de publication
06/2002
Volume
6
Numéro
2
Pages
129-33
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jun
Résumé
OBJECTIVES: A combination vaccine against hepatitis A and B provides the opportunity for simultaneous protection against both diseases with a single vaccine. This clinical study investigated the reactogenicity and immunogenicity of a combined hepatitis A and B vaccine (Twinrix, GlaxoSmithKline Biologicals, Rixensart, Belgium) in healthy Chilean adults between 18 and 40 years of age. METHODS: In total, 345 healthy, seronegative health care workers were enrolled and randomized to three groups who received one of three lots of Twinrix on a 0-, 1- and 6-month schedules. Blood samples were screened 1 month after each dose for anti-HAV and anti-HBs antibodies. Reactogenicity after each dose was assessed using diary cards. RESULTS: The nature and incidence of symptoms were similar to those reported for other Twinrix studies. Very few symptoms were scored as severe. Upon completion of the vaccination, all subjects had anti-HAV antibodies with titers $6000 mIU/mL, and all but one were protected against hepatitis B, with titers $4000 mIU/mL. CONCLUSIONS: We have demonstrated the high immunogenicity and tolerance of the combined hepatitis A and B vaccine. Combined vaccination has the advantage of offering dual protection with a reduction in the number of injections needed, lower associated costs, and a positive impact on compliance.
Mots-clé
Adolescent Adult Chile Double-Blind Method Female Health Hepatitis A Antibodies Hepatitis A Vaccines/*adverse effects/economics/*immunology Hepatitis A virus/*immunology Hepatitis Antibodies/blood Hepatitis B Antibodies/blood Hepatitis B Vaccines/*adverse effects/economics/*immunology Hepatitis B virus/*immunology Humans Immunization Schedule Male Middle Aged Vaccines, Combined/*adverse effects/economics/*immunology
Pubmed
Création de la notice
24/01/2008 21:10
Dernière modification de la notice
20/08/2019 14:06
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