Microangiopathy in mild chronic venous incompetence (CVI): morphological alterations and increased transcapillary diffusion detected by fluorescence videomicroscopy

Détails

ID Serval
serval:BIB_27792FDA1BF2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Microangiopathy in mild chronic venous incompetence (CVI): morphological alterations and increased transcapillary diffusion detected by fluorescence videomicroscopy
Périodique
International Journal of Microcirculation; Clinical and Experimental
Auteur(s)
Speiser  D. E., Bollinger  A.
ISSN
0167-6865 (Print)
Statut éditorial
Publié
Date de publication
02/1991
Volume
10
Numéro
1
Pages
55-66
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
We investigated morphology of skin capillaries and pericapillary halos and transcapillary diffusion of Na-fluorescein in 15 patients with mild chronic venous incompetence (CVI) and in 15 healthy controls. Transcutaneous fluorescence videomicroscopy was performed at the medial ankle region. To assess transcapillary diffusion the fluorescent light intensity was monitored within a densitometer window encompassing 3.2mm2 of skin surface. Only a few capillaries exhibited the features of microangiopathy described in patients with severe CVI. A minority of microvessels of the patients with mild CVI showed moderate dilations or increased tortuosity. Inhomogenous perfusion, extremely tortuous microvessels resembling glomeruli, obliterations of vessels or avascular fields frequent in severe forms of the disease were not detected and the density of skin capillaries was identical to controls. Although skin capillary alterations were mild or moderate, mean diameter and range of pericapillary halos were significantly (p less than 0.05) enhanced in the group with mild CVI, indicating increased transcapillary diffusion. This finding contrasts to the results in healthy volunteers and to the values previously measured in patients with severe CVI, in whom normal fluorescent light intensities were determined in skin areas of identical location and size. We conclude that in mild CVI enhanced transcapillary diffusion predominates, while morphological alterations of capillaries typical for severe CVI are just beginning to emerge.
Mots-clé
Capillaries/pathology/physiopathology Chronic Disease Diffusion Female Humans Male Microscopy, Fluorescence Middle Aged Severity of Illness Index Skin/*blood supply Venous Insufficiency/*pathology/physiopathology Video Recording
Pubmed
Web of science
Création de la notice
28/01/2008 12:33
Dernière modification de la notice
20/08/2019 14:06
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