The IFN gamma receptor: a paradigm for cytokine receptor signaling.

Détails

ID Serval
serval:BIB_2761C78CAE8F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The IFN gamma receptor: a paradigm for cytokine receptor signaling.
Périodique
Annual Review of Immunology
Auteur(s)
Bach E.A., Aguet M., Schreiber R.D.
ISSN
0732-0582 (Print)
ISSN-L
0732-0582
Statut éditorial
Publié
Date de publication
1997
Volume
15
Pages
563-591
Langue
anglais
Résumé
During the last several years, the mechanism of IFN gamma-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFN gamma-induced cellular responses. The structure and function of the IFN gamma receptor have been defined. The mechanism of IFN gamma signal transduction has been largely elucidated, and the physiologic relevance of this process validated. Most recently, the molecular events that link receptor ligation to signal transduction have been established. Together these insights have produced a model of IFN gamma signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily.
Mots-clé
Amino Acid Sequence, Animals, Humans, Ligands, Mice, Models, Biological, Models, Molecular, Molecular Sequence Data, Molecular Structure, Neoplasms/immunology, Protein Conformation, Receptors, Cytokine/physiology, Receptors, Interferon/chemistry, Receptors, Interferon/genetics, Signal Transduction
Pubmed
Web of science
Création de la notice
28/01/2008 12:36
Dernière modification de la notice
20/08/2019 14:06
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