Primary spinal epidural lymphoma: patients' profile, outcome, and prognostic factors: a multicenter Rare Cancer Network study

Détails

ID Serval
serval:BIB_275F5C3153A0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Primary spinal epidural lymphoma: patients' profile, outcome, and prognostic factors: a multicenter Rare Cancer Network study
Périodique
International Journal of Radiation Oncology, Biology, Physics
Auteur⸱e⸱s
Monnard  V., Sun  A., Epelbaum  R., Poortmans  P., Miller  R. C., Verschueren  T., Scandolaro  L., Villa  S., Majno  S. B., Ostermann  S., Ozsahin  M., Mirimanoff  R. O.
ISSN
0360-3016
Statut éditorial
Publié
Date de publication
07/2006
Peer-reviewed
Oui
Volume
65
Numéro
3
Pages
817-23
Notes
Journal Article
Multicenter Study --- Old month value: Jul 1
Résumé
PURPOSE: To assess the clinical profile, treatment outcome, and prognostic factors in primary spinal epidural lymphoma (PSEL). METHODS AND MATERIALS: Between 1982 and 2002, 52 consecutive patients with PSEL were treated in nine institutions of the Rare Cancer Network. Forty-eight patients had an Ann Arbor stage IE and four had a stage IIE. Forty-eight patients underwent decompressive laminectomy, all received radiotherapy (RT) with (n = 32) or without chemotherapy (n = 20). Median RT dose was 36 Gy (range, 6-50 Gy). RESULTS: Six (11%) patients progressed locally and 22 (42%) had a systemic relapse. At last follow-up, 28 patients were alive and 24 had died. The 5-year overall survival, disease-free survival, and local control were 69%, 57%, and 88%, respectively. In univariate analyses, favorable prognostic factors were younger age and complete neurologic response. Multivariate analysis showed that combined modality treatment, RT volume, total dose more than 36 Gy, tumor resection, and complete neurologic response were favorable prognostic factors. CONCLUSIONS: Primary spinal epidural lymphoma has distinct clinical features and outcome, with a relatively good prognosis. After therapy, local control is excellent and systemic relapse occurs in less than half the cases. Combined modality treatment appears to be superior to RT alone.
Mots-clé
Adult Aged Aged, 80 and over Analysis of Variance Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use Combined Modality Therapy/methods Epidural Space Female Humans Lymphoma, Non-Hodgkin/mortality/*therapy Male Middle Aged Radiation Injuries/etiology Radiotherapy Dosage Spinal Neoplasms/mortality/*therapy Survival Analysis Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 18:15
Dernière modification de la notice
20/08/2019 14:06
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