FXYD proteins: new tissue- and isoform-specific regulators of Na,K-ATPase

Détails

ID Serval
serval:BIB_272E72D46A34
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
FXYD proteins: new tissue- and isoform-specific regulators of Na,K-ATPase
Périodique
Annals of the New York Academy of Sciences
Auteur(s)
Geering  K., Beguin  P., Garty  H., Karlish  S., Fuzesi  M., Horisberger  J. D., Crambert  G.
ISSN
0077-8923 (Print)
Statut éditorial
Publié
Date de publication
04/2003
Volume
986
Pages
388-94
Notes
Journal Article
Review --- Old month value: Apr
Résumé
The recently defined FXYD protein family contains seven members that are small, single-span membrane proteins characterized by a signature sequence containing an FXYD motif and three other conserved amino acid residues. Until recently, the functional role of FXYD proteins was largely unknown, with the exception of the gamma subunit of Na,K-ATPase, which was shown to be a specific regulator of renal alpha1-beta1 isozymes. We have investigated whether other members of the FXYD family may have a similar role as the gamma subunit and have found that CHIF (corticosteroid hormone-induced factor, FXYD4), FXYD7, as well as phospholemman (FXYD1) specifically associate with Na,K-ATPase and preferentially with alpha1-beta isozymes in native tissues, and produce distinct effects on the transport properties of Na,K-ATPase that are adapted to the physiological demands of the tissues in which they are expressed. These results provide evidence for a unique and novel mode of regulation of Na,K-ATPase by FXYD proteins that involves a tissue-specific expression of an auxiliary subunit of distinct Na,K-ATPase isozymes.
Mots-clé
Amino Acid Sequence Animals Colon Conserved Sequence Intestinal Mucosa/enzymology Isoenzymes/chemistry/metabolism Kidney/*enzymology Lysosomes/enzymology Membrane Proteins/*metabolism Na(+)-K(+)-Exchanging ATPase/chemistry/*metabolism Neurons/enzymology Protein Subunits/chemistry/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 13:28
Dernière modification de la notice
20/08/2019 14:06
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