Evaluation of outer retinal tubulations in eyes switched from intravitreal ranibizumab to aflibercept for treatment of exudative age-related macular degeneration.

Détails

ID Serval
serval:BIB_272473C16989
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evaluation of outer retinal tubulations in eyes switched from intravitreal ranibizumab to aflibercept for treatment of exudative age-related macular degeneration.
Périodique
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Auteur(s)
Massamba N., Dirani A., Butel N., Fardeau C., Bodaghi B., Ingram A., Lehoang P.
ISSN
1435-702X (Electronic)
ISSN-L
0721-832X
Statut éditorial
Publié
Date de publication
01/2017
Peer-reviewed
Oui
Volume
255
Numéro
1
Pages
61-67
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To evaluate the changes of outer retinal tubulations (ORTs) as seen on spectral-domain optical coherence tomography (SD OCT) in eyes with neovascular age-related macular degeneration (AMD) where treatment was switched from intravitreal ranibizumab to intravitreal aflibercept.
This was a prospective study of eyes diagnosed with neovascular AMD and previously treated with >6 intravitreal ranibizumab injections and switched to aflibercept, conducted at a single centre (Department of Ophthalmology at Pitié Salpetriere Hospital, Paris VI University) from January to July 2015. Before and after treatment was switched from ranibizumab to aflibercept, SD-OCT was used to evaluate the presence of ORTs. Additional assessments in this patient group included best-corrected visual acuity (BCVA), fluorescein angiography (FA), indocyanine green angiography (ICGA). Changes in pigment epithelium detachments (PED), presence of intraretinal cysts, and presence of subretinal fluid (SRF) were also noted.
Twenty-four eyes of 24 consecutive patients (15 female/nine male, mean age 70 years) diagnosed with neovascular AMD and previously treated with >6 intravitreal ranibizumab injections and switched to aflibercept were included in the analysis. After receiving aflibercept, patients were followed for a mean of 6.1 months. Prior to treatment switch, 97 % of eyes showed ORTs, while after treatment switch to aflibercept, at the end of the study period, 75 % had ORTs (p =  0.219). Changes in BCVA (LogMAR) were not statistically significant (1.16 ± 0.44 to 1.18 ± 1.06, p =  0.12), however, a significant reduction in central macular thickness (CMT) (from 406 μm ± 112 to 263 μm ± 68, p =  0.001), PED (from 70.8 % to 41.7 % , p =  0.016), presence of intraretinal cysts (from 83.3 % to 33.3 %, p =  0.002) and SRF (from 91.7 % to 25 %, p = 0.001 ) were noted.
After switching from ranibizumab treatment to aflibercept, ORTs remained present in 75 % of eyes, and significant reductions in CMT, PED, and SRF, and presence of intraretinal cysts were observed.

Mots-clé
Aged, Angiogenesis Inhibitors/administration & dosage, Drug Substitution, Female, Fluorescein Angiography/methods, Follow-Up Studies, Fundus Oculi, Humans, Intravitreal Injections, Male, Middle Aged, Prospective Studies, Ranibizumab/administration & dosage, Receptors, Vascular Endothelial Growth Factor/administration & dosage, Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors, Recombinant Fusion Proteins/administration & dosage, Retinal Photoreceptor Cell Outer Segment/drug effects, Retinal Photoreceptor Cell Outer Segment/pathology, Tomography, Optical Coherence/methods, Treatment Outcome, Wet Macular Degeneration/diagnosis, Wet Macular Degeneration/drug therapy, Aflibercept, Anti-VEGF, Exudative AMD, Outer retinal tubulations, Ranibizumab, SD-OCT
Pubmed
Web of science
Création de la notice
19/07/2016 18:38
Dernière modification de la notice
20/08/2019 14:06
Données d'usage