Multiple roles of a trimeric G protein in Drosophila cell polarization.

Détails

Ressource 1Télécharger: BIB_271CE1477059.P001.pdf (1074.45 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_271CE1477059
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Multiple roles of a trimeric G protein in Drosophila cell polarization.
Périodique
Cell Cycle
Auteur⸱e⸱s
Katanaev V.L., Tomlinson A.
ISSN
1551-4005 (Electronic)
ISSN-L
1551-4005
Statut éditorial
Publié
Date de publication
2006
Volume
5
Numéro
21
Pages
2464-2472
Langue
anglais
Résumé
Polarization of the cellular cytoskeleton underlies many cellular processes including axon growth cone guidance, chemotaxis and yeast mating. Planar cell polarity (PCP) is a similar phenomenon in which cells in an epithelium become uniformly polarized to generate a field of aligned structures such as the hair cells of the cochlea. In Drosophila PCP is under the hierarchical control of Frizzled (Fz)-a serpentine receptor (that also functions in the Wnt signaling pathway). Serpentine receptors are routinely transduced by trimeric G-proteins, but until recently the general consensus was that Fzs were not G-protein linked. In Drosophila a G-protein (Galpha(o)) has now been identified that functions in both the Wnt and PCP pathways. Here we review the cell polarity phenotypes of Galpha(o) mutants and discuss the evidence that it plays multifarious roles in PCP and the organization of the cytoskeleton.
Mots-clé
Actins/metabolism, Animals, Cell Movement, Chemotaxis, Cytoskeleton/metabolism, Dimerization, Drosophila Proteins/metabolism, Drosophila Proteins/physiology, Drosophila melanogaster/genetics, Drosophila melanogaster/physiology, Epithelium/metabolism, Frizzled Receptors/metabolism, Frizzled Receptors/physiology, GTP-Binding Proteins/metabolism, Gene Expression Regulation, Models, Biological, Phenotype, Receptors, G-Protein-Coupled/metabolism, Receptors, G-Protein-Coupled/physiology, Signal Transduction, Wnt Proteins/metabolism
Pubmed
Web of science
Création de la notice
22/12/2011 17:14
Dernière modification de la notice
20/08/2019 14:06
Données d'usage