Benign pineal cysts in children with bilateral retinoblastoma: a new variant of trilateral retinoblastoma?

Détails

ID Serval
serval:BIB_27147CD06FA5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Benign pineal cysts in children with bilateral retinoblastoma: a new variant of trilateral retinoblastoma?
Périodique
Pediatric blood & cancer
Auteur(s)
Beck Popovic M., Balmer A., Maeder P., Braganca T., Munier F.L.
ISSN
1545-5009
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
46
Numéro
7
Pages
755-61
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
PURPOSE: Patients with hereditary retinoblastoma (Rb) develop in 4%-8% a malignant midline tumor called trilateral Rb (TRb). We report in this study on benign pineal cysts observed in patients investigated for TRb. PATIENTS AND METHODS: Between September 1990 and December 2001, 172 patients were screened for TRb. Ninty-five had bilateral, 77 unilateral disease. The median age at diagnosis of Rb was 7 months (range 1-26). Treatment included enucleation, local treatment with cryotherapy or photocoagulation, first-line chemotherapy (CT), thermo-chemotherapy (TCT), Ruthenium plaque, and, rarely, external beam radiation (EBR). RESULTS: TRb was found in 5/95 patients (5.3%) with bilateral disease. Interestingly, five other patients (5.3%) presented a pineal cyst on magnetic resonance imaging (MRI). No cysts were recorded in the 77 patients with unilateral disease. This difference was statistically significant (P < 0.05). The median age at diagnosis of the pineal cyst was 26 months (range 16-80), much younger than reported in literature for healthy children. Four of five patients with TRb died of the disease, while all the patients with pineal cysts remained stable and asymptomatic during a median follow-up of 41 months (range 37-54). CONCLUSIONS: This report describes benign cystic lesions of the pineal gland in patients with hereditary Rb, suggesting a benign variant of TRb. Underlying possible pathogenetic mechanisms are discussed.
Mots-clé
Brain Neoplasms, Central Nervous System Cysts, Child, Preschool, Humans, Infant, Magnetic Resonance Imaging, Pineal Gland, Pinealoma, Prognosis, Retinal Neoplasms, Retinoblastoma, Switzerland, Tomography, X-Ray Computed
Pubmed
Web of science
Création de la notice
20/03/2008 10:34
Dernière modification de la notice
20/08/2019 14:05
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