Application de la modélisation moléculaire à de nouvelles approches thérapeutiques du cancer [Application of molecular modeling to new therapeutic cancer approaches].

Détails

ID Serval
serval:BIB_26EE513BE64A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Application de la modélisation moléculaire à de nouvelles approches thérapeutiques du cancer [Application of molecular modeling to new therapeutic cancer approaches].
Périodique
Bulletin du Cancer
Auteur⸱e⸱s
Michielin O.
ISSN
1769-6917 (Electronic)
ISSN-L
0007-4551
Statut éditorial
Publié
Date de publication
2007
Volume
94
Numéro
9
Pages
763-768
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Résumé
Recent progress in the experimental determination of protein structures allow to understand, at a very detailed level, the molecular recognition mechanisms that are at the basis of the living matter. This level of understanding makes it possible to design rational therapeutic approaches, in which effectors molecules are adapted or created de novo to perform a given function. An example of such an approach is drug design, were small inhibitory molecules are designed using in silico simulations and tested in vitro. In this article, we present a similar approach to rationally optimize the sequence of killer T lymphocytes receptors to make them more efficient against melanoma cells. The architecture of this translational research project is presented together with its implications both at the level of basic research as well as in the clinics.
Mots-clé
Amino Acid Sequence, Amino Acid Substitution, Antigens, Neoplasm/immunology, Computer Simulation, Conserved Sequence, Humans, Immunotherapy, Adoptive, Melanoma/immunology, Melanoma/therapy, Membrane Proteins/immunology, Models, Molecular, Molecular Sequence Data, Neoplasm Proteins/antagonists & inhibitors, Neoplasm Proteins/chemistry, Protein Conformation, Protein Engineering/methods, Protein Interaction Mapping, Receptors, Antigen, T-Cell/chemistry, Receptors, Antigen, T-Cell/immunology, Sequence Alignment, Structure-Activity Relationship, T-Cell Antigen Receptor Specificity, T-Lymphocytes, Cytotoxic/chemistry, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:22
Dernière modification de la notice
20/08/2019 14:05
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