Detection of circulating tumour cell clusters in human glioblastoma.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_269BEE7656D8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Detection of circulating tumour cell clusters in human glioblastoma.
Périodique
British journal of cancer
Auteur(s)
Krol I., Castro-Giner F., Maurer M., Gkountela S., Szczerba B.M., Scherrer R., Coleman N., Carreira S., Bachmann F., Anderson S., Engelhardt M., Lane H., Evans TRJ, Plummer R., Kristeleit R., Lopez J., Aceto N.
ISSN
1532-1827 (Electronic)
ISSN-L
0007-0920
Statut éditorial
Publié
Date de publication
08/2018
Peer-reviewed
Oui
Volume
119
Numéro
4
Pages
487-491
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it is unclear whether multicellular CTC clusters are generated in this disease and whether they can bypass the physical hurdle of the blood-brain barrier. Here, we assessed CTC presence and composition at multiple time points in 13 patients with progressing GBM during an open-label phase 1/2a study with the microtubule inhibitor BAL101553. We observe CTC clusters ranging from 2 to 23 cells and present at multiple sampling time points in a GBM patient with pleomorphism and extensive necrosis, throughout disease progression. Exome sequencing of GBM CTC clusters highlights variants in 58 cancer-associated genes including ATM, PMS2, POLE, APC, XPO1, TFRC, JAK2, ERBB4 and ALK. Together, our findings represent the first evidence of the presence of CTC clusters in GBM.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/08/2018 9:03
Dernière modification de la notice
13/01/2021 8:08
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