mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_269214AFD133
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.
Périodique
Cell reports
Auteur(s)
Valentinova K., Mameli M.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
30/08/2016
Peer-reviewed
Oui
Volume
16
Numéro
9
Pages
2298-2307
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Excitatory and inhibitory transmission onto lateral habenula (LHb) neurons is instrumental for the expression of positive and negative motivational states. However, insights into the molecular mechanisms modulating synaptic transmission and the repercussions for neuronal activity within the LHb remain elusive. Here, we report that, in mice, activation of group I metabotropic glutamate receptors triggers long-term depression at excitatory (eLTD) and inhibitory (iLTD) synapses in the LHb. mGluR-eLTD and iLTD rely on mGluR1 and PKC signaling. However, mGluR-dependent adaptations of excitatory and inhibitory synaptic transmission differ in their expression mechanisms. mGluR-eLTD occurs via an endocannabinoid receptor-dependent decrease in glutamate release. Conversely, mGluR-iLTD occurs postsynaptically through PKC-dependent reduction of β2-containing GABAA-R function. Finally, mGluR-dependent plasticity of excitation or inhibition decides the direction of neuronal firing, providing a synaptic mechanism to bidirectionally control LHb output. We propose mGluR-LTD as a cellular substrate that underlies LHb-dependent encoding of opposing motivational states.

Pubmed
Web of science
Open Access
Oui
Création de la notice
31/01/2017 11:11
Dernière modification de la notice
20/08/2019 13:05
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