Targeting the tumor vasculature to enhance T cell activity.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_266C11B75B8F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Targeting the tumor vasculature to enhance T cell activity.
Périodique
Current Opinion in Immunology
Auteur(s)
Lanitis E., Irving M., Coukos G.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
33
Pages
55-63
Langue
anglais
Résumé
T cells play a critical role in tumor immune surveillance as evidenced by extensive mouse-tumor model studies as well as encouraging patient responses to adoptive T cell therapies and dendritic cell vaccines. It is well established that the interplay of tumor cells with their local cellular environment can trigger events that are immunoinhibitory to T cells. More recently it is emerging that the tumor vasculature itself constitutes an important barrier to T cells. Endothelial cells lining the vessels can suppress T cell activity, target them for destruction, and block them from gaining entry into the tumor in the first place through the deregulation of adhesion molecules. Here we review approaches to break this tumor endothelial barrier and enhance T cell activity.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/05/2015 17:06
Dernière modification de la notice
20/08/2019 13:05
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