High density lipoproteins (HDL) in women with postmenopausal osteoporosis: a preliminary study.
Détails
ID Serval
serval:BIB_26315FF961BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
High density lipoproteins (HDL) in women with postmenopausal osteoporosis: a preliminary study.
Périodique
Menopause
ISSN
1072-3714 (Print)
ISSN-L
1072-3714
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
8
Numéro
6
Pages
429-432
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Since a previous study showed an inverse correlation between high density lipoproteins (HDL) and bone mineral density (BMD), we searched for a possible relationship between HDL level and the presence of postmenopausal osteoporosis.
We measured HDL levels in 37 women with postmenopausal osteoporosis, and compared them with a control group of 43 healthy postmenopausal women. The HDL levels were compared between the two groups using Student's t test and were correlated with BMD by Pearson's coefficient. To avoid possible selection bias, we compared patients and controls for body mass index by chi 2 test. The sensitivity and specificity of HDL level higher than 65 mg% (positive test) or lower than 45 mg% (negative test) was compared with double emission x-ray absorptiometry (considered the gold standard in the measurement of BMD).
The level of HDL was significantly higher in the osteoporotic patients than in the controls (67.7 +/- 15.5 mg% vs 58.3 +/- 11.6 mg%, p = 0.0039). HDL was inversely correlated with BMD (r = -0.29, p = 0.0083). HDL higher than 65 mg% has a high specificity (77%) for patients with osteoporosis, while HDL lower than 45 mg% has a high sensitivity (97%) in detecting subject without osteoporosis.
Our preliminary data suggest an interesting, as yet unexplained association between HDL and bone mineral density in postmenopausal women.
We measured HDL levels in 37 women with postmenopausal osteoporosis, and compared them with a control group of 43 healthy postmenopausal women. The HDL levels were compared between the two groups using Student's t test and were correlated with BMD by Pearson's coefficient. To avoid possible selection bias, we compared patients and controls for body mass index by chi 2 test. The sensitivity and specificity of HDL level higher than 65 mg% (positive test) or lower than 45 mg% (negative test) was compared with double emission x-ray absorptiometry (considered the gold standard in the measurement of BMD).
The level of HDL was significantly higher in the osteoporotic patients than in the controls (67.7 +/- 15.5 mg% vs 58.3 +/- 11.6 mg%, p = 0.0039). HDL was inversely correlated with BMD (r = -0.29, p = 0.0083). HDL higher than 65 mg% has a high specificity (77%) for patients with osteoporosis, while HDL lower than 45 mg% has a high sensitivity (97%) in detecting subject without osteoporosis.
Our preliminary data suggest an interesting, as yet unexplained association between HDL and bone mineral density in postmenopausal women.
Mots-clé
Absorptiometry, Photon, Bone Density, Case-Control Studies, Female, Humans, Lipoproteins, HDL/blood, Middle Aged, Osteoporosis, Postmenopausal/blood, Sensitivity and Specificity
Pubmed
Web of science
Création de la notice
23/01/2020 15:45
Dernière modification de la notice
24/01/2020 7:26