Performance of 18F-fluoro-ethyl-tyrosine (18F-FET) PET for the differential diagnosis of primary brain tumor: a systematic review and Metaanalysis.

Détails

ID Serval
serval:BIB_261ECB42CC1A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Performance of 18F-fluoro-ethyl-tyrosine (18F-FET) PET for the differential diagnosis of primary brain tumor: a systematic review and Metaanalysis.
Périodique
Journal of nuclear medicine
Auteur⸱e⸱s
Dunet V., Rossier C., Buck A., Stupp R., Prior J.O.
ISSN
1535-5667 (Electronic)
ISSN-L
0161-5505
Statut éditorial
Publié
Date de publication
02/2012
Peer-reviewed
Oui
Volume
53
Numéro
2
Pages
207-214
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Résumé
For the past decade, PET with (18)F-fluoro-ethyl-tyrosine ((18)F-FET) has been used in the evaluation of patients with primary brain tumors (PBTs), but so far series have reported only a limited number of patients. The purpose of this systematic review and metaanalysis was to assess the diagnostic performance of (18)F-FET PET in patients with suspicion of PBT.
We examined studies published in the literature using MEDLINE and EMBASE databases. Inclusion criteria were use of (18)F-FET PET for initial assessment of patients with a newly diagnosed brain lesion; patients who had no radiotherapy, surgery, or chemotherapy before (18)F-FET PET; and use of histology as a gold standard. Metaanalysis was performed on a per-patient basis. We secondarily performed receiver-operating-characteristic analysis of pooled patients to determine tumor-to-background ratio (TBR) of (18)F-FET uptake and best diagnostic value.
Thirteen studies totaling 462 patients were included. For the diagnosis of PBT, (18)F-FET PET demonstrated a pooled sensitivity of 0.82 (95% confidence interval [CI], 0.74-0.88), specificity of 0.76 (95% CI, 0.44-0.92), area under the curve of 0.84 (95% CI, 0.80-0.87), positive likelihood ratio of 3.4 (95% CI, 1.2-9.5), and negative likelihood ratio of 0.24 (95% CI, 0.14-0.39). Receiver-operating-characteristic analysis indicated that a mean TBR threshold of at least 1.6 and a maximum TBR of at least 2.1 had the best diagnostic value for differentiating PBTs from nontumoral lesions.
(18)F-FET PET demonstrated excellent performance for diagnosing PBTs. Strict standardization of PET acquisition protocols and prospective, multicenter studies investigating the added value over current MRI are now needed to establish (18)F-FET PET as a highly relevant tool for patient management.

Mots-clé
Animals, Brain Neoplasms/diagnostic imaging, Diagnosis, Differential, Glioma/diagnostic imaging, Humans, Positron-Emission Tomography/methods, Quality Control, Tyrosine/analogs & derivatives
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/03/2012 16:11
Dernière modification de la notice
20/08/2019 13:04
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