DDR1 role in fibrosis and its pharmacological targeting.

Détails

ID Serval
serval:BIB_25F81C67012D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
DDR1 role in fibrosis and its pharmacological targeting.
Périodique
Biochimica et biophysica acta. Molecular cell research
Auteur(s)
Moll S., Desmoulière A., Moeller M.J., Pache J.C., Badi L., Arcadu F., Richter H., Satz A., Uhles S., Cavalli A., Drawnel F., Scapozza L., Prunotto M.
ISSN
1879-2596 (Electronic)
ISSN-L
0167-4889
Statut éditorial
Publié
Date de publication
11/2019
Peer-reviewed
Oui
Volume
1866
Numéro
11
Pages
118474
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways; however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts. Increased expression of DDR1 has been documented in several types of cancer and fibrotic conditions including skin hypertrophic scars, idiopathic pulmonary fibrosis, cirrhotic liver and renal fibrosis. The present review article focuses on: a) detailing the evidence for a role of DDR1 as an anti-fibrotic target in different organs, b) clarifying DDR1 tissue distribution in healthy and diseased tissues as well as c) exploring DDR1 protective mode of action based on literature evidence and co-authors experience; d) detailing pharmacological efforts attempted to drug this subtle anti-fibrotic target to date.
Mots-clé
Animals, Atherosclerosis/metabolism, Discoidin Domain Receptor 1/drug effects, Discoidin Domain Receptor 1/metabolism, Epithelial Cells/metabolism, Epithelial Cells/pathology, Fibroblasts/metabolism, Fibroblasts/pathology, Fibrosis/drug therapy, Fibrosis/metabolism, Humans, Kidney/metabolism, Kidney/pathology, Liver/metabolism, Liver/pathology, Lung/metabolism, Lung/pathology, Mice, Neoplasms/metabolism, Nephritis, Interstitial/pathology, Plasma Cells, Receptor Protein-Tyrosine Kinases, Skin/metabolism, Skin/pathology, Vascular Diseases/metabolism, Wound Healing, DDR1, Fibrosis, Kidney, Lung, Skin, Tyrosine kinase
Pubmed
Web of science
Création de la notice
15/04/2019 18:40
Dernière modification de la notice
23/01/2020 7:19
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