Characterization of two receptors for TRAIL.
Détails
Télécharger: BIB_25D695CC2FFE.P001.pdf (942.94 [Ko])
Etat: Public
Version: de l'auteur⸱e
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_25D695CC2FFE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Characterization of two receptors for TRAIL.
Périodique
FEBS letters
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
416
Numéro
3
Pages
329-34
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Two receptors for TRAIL, designated TRAIL-R2 and TRAIL-R3, have been identified. Both are members of the tumor necrosis factor receptor family. TRAIL-R2 is structurally similar to the death-domain-containing receptor TRAIL-R1 (DR-4), and is capable of inducing apoptosis. In contrast, TRAIL-R3 does not promote cell death. TRAIL-R3 is highly glycosylated and is membrane bound via a putative phosphatidylinositol anchor. The extended structure of TRAIL-R3 is due to the presence of multiple threonine-, alanine-, proline- and glutamine-rich repeats (TAPE repeats). TRAIL-R2 shows a broad tissue distribution, whereas the expression of TRAIL-R3 is restricted to peripheral blood lymphocytes (PBLs) and skeletal muscle. All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals.
Mots-clé
Amino Acid Sequence, Apoptosis, Apoptosis Regulatory Proteins, Cell Line, Chromosome Mapping, Cloning, Molecular, Humans, Kinetics, Lymphocytes, Membrane Glycoproteins, Molecular Sequence Data, Muscle, Skeletal, Polymerase Chain Reaction, Receptors, TNF-Related Apoptosis-Inducing Ligand, Receptors, Tumor Necrosis Factor, Recombinant Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Sequence Tagged Sites, Signal Transduction, TNF-Related Apoptosis-Inducing Ligand, Transfection, Tumor Necrosis Factor Decoy Receptors, Tumor Necrosis Factor-alpha
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 14:04