Arsenic may be a carcinogenic determinant of a subset of gallbladder cancer: a pilot study.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_2564C04FBC9B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Arsenic may be a carcinogenic determinant of a subset of gallbladder cancer: a pilot study.
Périodique
Environmental research
ISSN
1096-0953 (Electronic)
ISSN-L
0013-9351
Statut éditorial
Publié
Date de publication
15/02/2023
Peer-reviewed
Oui
Volume
219
Pages
115030
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Gallbladder cancer (GBC) is one of the deadliest malignancy and treatment options are deplorably limited. Better strategies of prevention are urgently needed but knowledge on risk factors remains scarce. Recent data suggested that arsenic (As) may be involved in GBC carcinogenesis but the question remains debated. To date, there are no data on As measurement in GBC samples. This pilot study aimed to measure As concentrations in tissue samples from patients with GBC compared to non-cancerous gallbladder (NCGB). Included patients underwent cholecystectomy at Hospital Clinico Universidad de Chile, Santiago in Chile, a country with high As exposure, between 2001 and 2020. Tissue samples were preserved in formalin-fixed, paraffin-embedded blocks. Selected samples were retrieved, processed and submitted to inductively coupled plasma mass spectrometry (ICP-MS) to determine As concentrations. A total of 77 patients were included, including 35 GBC and 42 NCGB. The two groups were comparable, except for age (68 vs. 49 years, p < 0.001). Measured in 11 GBC and 38 NCGB, total As was detected in 5 GBC (14%) compared to 0 NCGB samples (p < 0.001). GBC group also showed higher median values of As compared to NCGB (p < 0.001). This pilot study provided a proof-of-concept to measure As concentrations in gallbladder samples and showed higher level of As in GBC samples compared to NCGB, paving the way for future studies aiming to investigate the impact of As on GBC, which may contribute to the prevention of this deadly disease.
Mots-clé
Humans, Gallbladder Neoplasms/epidemiology, Gallbladder Neoplasms/etiology, Gallbladder Neoplasms/pathology, Arsenic, Pilot Projects, Carcinogens, Carcinogenesis, Carcinogen, Exposure, Heavy metals, Prevention, Toxicants
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/12/2022 11:15
Dernière modification de la notice
24/10/2023 7:13